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| Registros recuperados : 27 | |
| 2. |  | SILVA, M. V. G. B.; VERARDO, L. L.; MACHADO, M. A.; PANETTO, J. C. do C.; CAROLINO, I.; CAROLINO, N. Candidate genes for disease, reproduction and meat quality traits in Portuguese native breeds. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings... Rotterdam: [s.n.], 2022.| Biblioteca(s): Embrapa Gado de Leite. |
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| 3. | | ALMEIDA, E. A. R.; PEREIRA, J. R.; CARVALHO, L. S.; SILVA, M. V. G. B.; MAGALHÃES, A. F. B.; VERARDO, L. L. Análises pós-estudo de associação no genoma de bovinos da raça Gir para a identificação de genes candidatos para perfil de ácidos graxos no leite. In: SIMPÓSIO DE PRODUÇÃO ANIMAL, 7.; SIMPÓSIO DO PROGRAMA DE PÓS-GRADUAÇÃO, 2.; SEMANA DA ZOOTECNIA, 15., 2023, Diamantina. Rumo ao futuro: [anais]. Diamantina: Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2023. p. 36-38.| Biblioteca(s): Embrapa Gado de Leite. |
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| 4. | | CARVALHO, L. S.; ALMEIDA, E. A. R.; SOUZA, K. G. L. de; SILVA, M. V. G. B.; MAGALHÃES, A. F. B.; VERARDO, L. L. Análise funcional de genes candidatos associados à resistência ao carrapato em bovinos da raça Gir. In: SIMPÓSIO DE PRODUÇÃO ANIMAL, 7.; SIMPÓSIO DO PROGRAMA DE PÓS-GRADUAÇÃO, 2.; SEMANA DA ZOOTECNIA, 15., 2023, Diamantina. Rumo ao futuro: [anais]. Diamantina: Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2023. p. 24-26.| Biblioteca(s): Embrapa Gado de Leite. |
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| 5. | | VERARDO, L. L.; SILVA, F. F.; VARONA, L.; RESENDE, M. D. V. de; BASTIAANSEN, J. W. M.; LOPES, P. S.; GUIMARÃES, S. E. F. Bayesian GWAS and network analysis revealed new candidate genes for number of teats in pigs. Journal of Applied Genetics, v. 56, n. 1, p. 123-132, Feb. 2015.| Biblioteca(s): Embrapa Florestas. |
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| 6. | | FERNANDES, A. A. S.; VIEIRA, J. I. G.; FERREIRA, P. H.; MAGALHÃES, A. F. B.; SILVA, M. V. G. B.; VERARDO, L. L. An insertion in Caracu breed genome with a possible role in fatty acids profile. In: REUNIÃO DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 57., 2022, Campinas. Tropical animal science and pratice to feed the planet: proceedings. Brasília, DF: Sociedade Brasileira de Zootecnia; São Carlos, SP: Embrapa Pecuária Sudeste, 2022. p. 232.| Biblioteca(s): Embrapa Gado de Leite. |
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| 7. | | PANETTO, J. C. do C.; VERARDO, L. L.; MACHADO, M. A.; MARTINS, M. F.; FAZA, D. R. L. R.; SILVA, M. V. G. B. Genotype by environment interaction in Brazilian Dairy Gir cattle. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland. Proceedings... [S.l.: s.n.], 2018.| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | VERARDO, L. L.; STAFUZZA, N. B.; MUNARI, D. P.; ZERLOTINI NETO, A.; CHUD, T. C. S.; GARRICK, D. J.; COLE, J. B.; PANETTO, J. C. do C.; MACHADO, M. A.; MARTINS, M. F.; SILVA, M. V. G. B. A gene-transcription factor network associated with residual feed intake based on SNVs/InDels identified in Gir, Girolando and Holstein cattle breeds. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland. Proceedings... [S.l.: s.n.], 2018.| Biblioteca(s): Embrapa Gado de Leite. |
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| 9. | | VERARDO, L. L.; STAFUZZA, N. B.; MUNARI, D. P.; ZERLOTINI NETO, A.; CHUD, T. C. S.; GARRICK, D. J.; COLE, J. B.; PANETTO, J. C. do C.; MACHADO, M. A.; MARTINS, M. F.; SILVA, M. V. G. B. A gene-transcription factor network associated with residual feed intake based on SNVs/InDels identified in Gir, Girolando and Holstein cattle breeds. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland. Proceedings... [S.l.: s.n.], 2018. 6 p. Na publicação: A. Zerlotini, J. C. C. Panetto. WCGALP 2018.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 10. | | DUARTE, D. A. S.; FORTES, M. R. S.; DUARTE, M. de S.; GUIMARÃES, S. E. F.; VERARDO, L. L.; VERONEZE, R.; RIBEIRO, A. M. F.; LOPES, P. S.; RESENDE, M. D. V. de; SILVA, F. F. e. Genome-wide association studies, meta-analyses and derived gene network for meat quality and carcass traits in pigs. Animal Production Science, v. 58, n. 6, p. 1100-1008, May 2018.| Biblioteca(s): Embrapa Florestas. |
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| 11. | | PEREIRA, H. P.; VERARDO, L. L.; WELLER, M. M. D. C. A.; SBARDELLA, A. P.; MUNARI, D. P.; DAIBERT, R. M. de P.; CARVALHO, W. A.; MACHADO, M. A.; MARTINS, M. F. Going further post-RNA-seq: in silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle. Journal of Dairy Research, v. 88, p. 286-292, 2021.| Biblioteca(s): Embrapa Gado de Leite. |
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| 12. | | VERARDO, L. L.; NASCIMENTO, C. S.; SILVA, F. F.; GASPARINO, E.; MARTINS, M. F.; TORIYAMA, E.; FARIA, V. R.; BOTELHO, M. E.; COSTA, K. A.; LOPES, P. S.; GUIMARÃES, S. E. F. Identification and validation of differentially expressed genes from pig skeletal muscle. Journal of Animal Breeding and Genetics, v. 130, n. 5, p. 372-381, 2012.| Biblioteca(s): Embrapa Gado de Leite. |
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| 13. | | CAMPOS, B. M.; CARMO, A. S. do; SILVA, T. B. R. da; VERARDO, L. L.; GOUVEIA, J. J. de S.; MALHADO, C. H. M.; SILVA, M. V. G. B.; CARNEIRO, P. L. S. Identification of artificial selection signatures in Caracu breed lines selected for milk production and meat production. Livestock Science, v. 206, p. 82-87, 2017.| Biblioteca(s): Embrapa Gado de Leite. |
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| 14. | | VERARDO, L. L.; OTTO, P. I.; MACHADO, M. A.; PANETTO, J. C. do C.; REIS, D. R. de L.; EGITO, A. A. do; VITORINO, A. S. M.; CAROLINO, M. I. C. M.; CAROLINO, N. P.; SILVA, M. V. G. B. Exploring the genetic origin of Brazilian locally adapted breeds: admixture, population history and relationship with Portuguese and indicine cattle. Livestock Science, v. 282, 105455, 2024.| Biblioteca(s): Embrapa Gado de Leite. |
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| 15. | | NASCIMENTO, C. S.; PEIXOTO, J. de O.; VERARDO, L. L.; CAMPOS, C. F.; WELLER, M. M. C.; FARIA, V. R.; BOTELHO, M. E.; MARTINS, M. F.; MACHADO, M. A.; SILVA, F. F.; LOPES, P. S.; GUIMARÃES, S. E. F. Transcript profiling of expressed sequence tag from semimembranosus muscle of commercial and naturalized pig breeds. Genetics and Molecular Research, v. 11, n. 3, p. 3315-3328. 2012.| Biblioteca(s): Embrapa Gado de Leite. |
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| 16. | | SANTOS, C. G. dos; SOUSA, M. F.; VIEIRA, J. I. G.; MORAIS, L. R. de; FERNANDES, A. A. S.; LITTIERE, T. de O.; OTTO, P. I.; MACHADO, M. A.; SILVA, M. V. G. B.; BONAFÉ, C. M.; MAGALHÃES, A. F. B.; VERARDO, L. L. Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data. Journal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022.| Biblioteca(s): Embrapa Gado de Leite. |
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| 17. | | VERARDO, L. L.; SILVA, F. F. e; MACHADO, M. A.; PANETTO, J. C. do C.; REIS, D. R. de L.; OTTO, P. I.; REGITANO, L. C. de A.; SILVA, L. O. C. da; EGITO, A. A. do; ALBUQUERQUE, M. do S. M.; ZANELLA, R.; SILVA, M. V. G. B. Genome-wide analyses reveal the genetic architecture and candidate genes of indicine, taurine, synthetic crossbreds, and locally adapted cattle in Brazil. Frontiers in Genetics, v. 12, article 702822, 2021.| Biblioteca(s): Embrapa Gado de Corte; Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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| 18. | | OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SEVILLANO, C. A.; MARQUES, D. B. D.; PIRES, M. de F. A.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle. Journal of Dairy Science, v. 102, n. 9, p. 8148-8158, 2019.| Biblioteca(s): Embrapa Gado de Leite. |
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| 19. | | OTTO, P. I.; GUIMARAES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; SEVILLANO, C. A.; PRATA, M. C. de A.; FURLONG, J.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GARCIA, A. O.; DAIBERT, R. M. de P.; SILVA, M. V. G. B.; MACHADO, M. A. Genome wide association study for gastrointestinal nematodes resistance in Bos taurus x Bos indicus crossbred cattle. Livestock Science, v. 245, 104403, 2021. Short communication.| Biblioteca(s): Embrapa Gado de Leite. |
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| 20. | | CAMPOS, B. M.; CARMO, A. S. do; EGITO, A. A. do; MARIANTE, A. da S.; ALBUQUERQUE, M. S. M. do; GOUVEIA, J. J. S. de; MALHADO, C. H. M.; VERARDO, L. L.; SILVA, M. V. G. B. da; CARNEIRO, P. L. S. Genetic diversity, population structure, and correlations between locally adapted zebu and taurine breeds in Brazil using SNP markers. Tropical Animal Health and Production, v. 49, n. 8, p 1677-1684, 2017.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 27 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
09/01/2020 |
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Data da última atualização: |
06/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SEVILLANO, C. A.; MARQUES, D. B. D.; PIRES, M. de F. A.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. |
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Afiliação: |
ANA LUISA SOUSA AZEVEDO, CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; CELIO DE FREITAS, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
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Título: |
Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Journal of Dairy Science, v. 102, n. 9, p. 8148-8158, 2019. |
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DOI: |
https://doi.org/10.3168/jds.2018-15305 |
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Idioma: |
Inglês |
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Conteúdo: |
Heat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle. MenosHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔR... Mostrar Tudo |
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Palavras-Chave: |
Crossbred cattle; Gene network; Post-GWAS analyses. |
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Thesaurus NAL: |
Heat stress. |
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Categoria do assunto: |
-- |
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Marc: |
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001 2118465
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008 2019 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3168/jds.2018-15305$2DOI
100 1 $aOTTO, P. I.
245 $aGenome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle.$h[electronic resource]
260 $c2019
520 $aHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle.
650 $aHeat stress
653 $aCrossbred cattle
653 $aGene network
653 $aPost-GWAS analyses
700 1 $aGUIMARÃES, S. E. F.
700 1 $aVERARDO, L. L.
700 1 $aAZEVEDO, A. L. S.
700 1 $aVANDENPLAS, J.
700 1 $aSEVILLANO, C. A.
700 1 $aMARQUES, D. B. D.
700 1 $aPIRES, M. de F. A.
700 1 $aFREITAS, C. de
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aPANETTO, J. C. do C.
700 1 $aCARVALHO, W. A.
700 1 $aGOBO, D. O. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aMACHADO, M. A.
773 $tJournal of Dairy Science$gv. 102, n. 9, p. 8148-8158, 2019.
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